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Best 340B Program Management Tools in 2026
We compared 5 340b program management solutions to help you find the right fit for your team.
Last updated: May 2, 2026 ยท Reviewed by Tim
Our Top Picks
Editor's Choice#1 Pick
Aventi Health
aventihealth.com
Best for: Covered entities and pharmacies managing 340B programs
Over 300 covered entities and 1,000 pharmacies served
#2 Pick
Macro Helix
macrohelix.com
Best for: Hospitals, health systems, clinics, and retail pharmacies managing 340B programs
Serves 1000 covered entity clients in 48 states, partnering with approximately 40% of 340B-eligible hospitals in the U.S.
#3 Pick
340B Orphan Drug Solutions
340borphandrugsolutions.com
Best for: Hospitals and healthcare facilities managing 340B orphan drug programs
Helped hospitals save over $500 million
All 340B Program Management Tools Compared
| Tool | Pricing | Key Features | Best For |
|---|---|---|---|
| Quote-Based | Modern technology toolsRobust reporting and analytics | Covered entities and pharmacies managing 340B programs | |
| Quote-Based | Split billing and contract pharmacy softwareAdvanced data and analytics tools | Hospitals, health systems, clinics, and retail pharmacies managing 340B programs | |
| Quote-Based | Customized orphan drug listsSeamless split billing integration | Hospitals and healthcare facilities managing 340B orphan drug programs | |
| Quote-Based | Specialty Rx Referral CapturePrecision-Powered Rx Auditing | Healthcare providers managing 340B contract pharmacy networks | |
| Quote-Based | Automated claims reprocessingReal-time data monitoring | Healthcare providers managing 340B pharmacy and revenue operations |
Aventi HealthQuote-Based
Covered entities and pharmacies managing 340B programs
Modern technology toolsRobust reporting and analytics
Macro HelixQuote-Based
Hospitals, health systems, clinics, and retail pharmacies managing 340B programs
Split billing and contract pharmacy softwareAdvanced data and analytics tools
340B Orphan Drug SolutionsQuote-Based
Hospitals and healthcare facilities managing 340B orphan drug programs
Customized orphan drug listsSeamless split billing integration
SeleroQuote-Based
Healthcare providers managing 340B contract pharmacy networks
Specialty Rx Referral CapturePrecision-Powered Rx Auditing
ProximityQuote-Based
Healthcare providers managing 340B pharmacy and revenue operations
Automated claims reprocessingReal-time data monitoring
What to Look For in 340B Program Management Tools
The pricing landscape for 340b program management tools breaks down like this: 100% offer quote-based pricing. Key features to compare include modern technology tools, robust reporting and analytics, seamless onboarding and compliance. These tools serve a range of users. Matching the product to your actual workflow matters more than counting features.
Detailed Look at Top 340B Program Management Tools
Aventi Health
Quote-Based
Aventi Health offers a comprehensive 340B management platform and third-party administration services focused on specialty and infusion pharmacies, enabling compliant, efficient, and transparent drug discount program management. Notable: Over 300 covered entities and 1,000 pharmacies served. Pricing available upon request.
- Modern technology tools
- Robust reporting and analytics
- Seamless onboarding and compliance
Macro Helix
Quote-Based
Macro Helix offers comprehensive pharmacy management solutions tailored for 340B programs, including software, analytics, compliance, and contract pharmacy management to improve healthcare equity and operational efficiency. Notable: Serves 1000 covered entity clients in 48 states, partnering with approximately 40% of 340B-eligible hospitals in the U.S.. Pricing available upon request.
- Split billing and contract pharmacy software
- Advanced data and analytics tools
- HRSA compliance and audit services
340B Orphan Drug Solutions
Quote-Based
A turn-key orphan drug system designed specifically for hospitals to identify and capture hidden savings, automate quarterly updates, and integrate seamlessly with existing workflows. Notable: Helped hospitals save over $500 million. Pricing available upon request.
- Customized orphan drug lists
- Seamless split billing integration
- Automated quarterly updates
Selero
Quote-Based
Selero offers an advanced platform for managing and optimizing 340B drug programs with analytics, audit, and claim reporting tools. Pricing available upon request.
- Specialty Rx Referral Capture
- Precision-Powered Rx Auditing
- Fully Managed Claim Reporting
Proximity
Quote-Based
Proximity is a comprehensive platform designed to automate and optimize revenue operations for 340B drug programs, ensuring compliance, maximizing savings, and simplifying complex workflows. Notable: Trusted by numerous healthcare organizations and trusted logos. Pricing available upon request.
- Automated claims reprocessing
- Real-time data monitoring
- Configurable workflows
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Frequently Asked Questions
What is the best 340b program management tool in 2026?+
Of the 5 tools we reviewed, Aventi Health has the most complete profile. Aventi Health offers a comprehensive 340B management platform and third-party administration services focused on specialty and infusion pharmacies, enabling compliant, efficient, and transparent drug discount program management. Over 300 covered entities and 1,000 pharmacies served. The best choice depends on your needs, team size, and budget.
What features should I look for in 340b program management software?+
The most common features across 340b program management tools include Modern technology tools, Robust reporting and analytics, Seamless onboarding and compliance, Split billing and contract pharmacy software. The actual differentiators tend to be how well the tool fits your specific workflow, how well it integrates with your existing tech stack, and the quality of customer support.
How did SaaS Choice evaluate these 340b program management tools?+
We scored each tool on pricing transparency, feature completeness, target audience fit, and available social proof. Tools that provide clear pricing and audience information score higher.
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