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Best 340B Program Management Tools in 2026
We compared 5 340b program management solutions to help you find the right fit for your team.
Last updated: April 3, 2026
Our Top Picks
Editor's Choice#1 Pick
Aventi Health
aventihealth.com
Best for: Covered entities and pharmacies managing 340B programs
Over 300 covered entities and 1,000 pharmacies served
#2 Pick
Macro Helix
macrohelix.com
Best for: Hospitals, health systems, clinics, and retail pharmacies managing 340B programs
Serves 1000 covered entity clients in 48 states, partnering with approximately 40% of 340B-eligible hospitals in the U.S.
#3 Pick
340B Orphan Drug Solutions
340borphandrugsolutions.com
Best for: Hospitals and healthcare facilities managing 340B orphan drug programs
Helped hospitals save over $500 million
All 340B Program Management Tools Compared
| Tool | Pricing | Key Features | Best For |
|---|---|---|---|
| Contact Sales | Modern technology toolsRobust reporting and analytics | Covered entities and pharmacies managing 340B programs | |
| Contact Sales | Split billing and contract pharmacy softwareAdvanced data and analytics tools | Hospitals, health systems, clinics, and retail pharmacies managing 340B programs | |
| Contact Sales | Customized orphan drug listsSeamless split billing integration | Hospitals and healthcare facilities managing 340B orphan drug programs | |
| Contact Sales | Specialty Rx Referral CapturePrecision-Powered Rx Auditing | Healthcare providers managing 340B contract pharmacy networks | |
| Contact Sales | Automated claims reprocessingReal-time data monitoring | Healthcare providers managing 340B pharmacy and revenue operations |
Aventi HealthContact Sales
Covered entities and pharmacies managing 340B programs
Modern technology toolsRobust reporting and analytics
Macro HelixContact Sales
Hospitals, health systems, clinics, and retail pharmacies managing 340B programs
Split billing and contract pharmacy softwareAdvanced data and analytics tools
340B Orphan Drug SolutionsContact Sales
Hospitals and healthcare facilities managing 340B orphan drug programs
Customized orphan drug listsSeamless split billing integration
SeleroContact Sales
Healthcare providers managing 340B contract pharmacy networks
Specialty Rx Referral CapturePrecision-Powered Rx Auditing
ProximityContact Sales
Healthcare providers managing 340B pharmacy and revenue operations
Automated claims reprocessingReal-time data monitoring
What to Look For in 340B Program Management Tools
When evaluating 340b program management tools, consider the pricing landscape: 100% offer contact sales pricing. Key features to compare include modern technology tools, robust reporting and analytics, seamless onboarding and compliance. These tools serve a range of users, so matching the product to your specific workflow matters more than feature count.
Detailed Look at Top 340B Program Management Tools
Aventi Health
Contact Sales
Aventi Health offers a comprehensive 340B management platform and third-party administration services focused on specialty and infusion pharmacies, enabling compliant, efficient, and transparent drug discount program management. Notable: Over 300 covered entities and 1,000 pharmacies served. Available with contact sales pricing.
- Modern technology tools
- Robust reporting and analytics
- Seamless onboarding and compliance
Macro Helix
Contact Sales
Macro Helix offers comprehensive pharmacy management solutions tailored for 340B programs, including software, analytics, compliance, and contract pharmacy management to improve healthcare equity and operational efficiency. Notable: Serves 1000 covered entity clients in 48 states, partnering with approximately 40% of 340B-eligible hospitals in the U.S.. Available with contact sales pricing.
- Split billing and contract pharmacy software
- Advanced data and analytics tools
- HRSA compliance and audit services
340B Orphan Drug Solutions
Contact Sales
A turn-key orphan drug system designed specifically for hospitals to identify and capture hidden savings, automate quarterly updates, and integrate seamlessly with existing workflows. Notable: Helped hospitals save over $500 million. Available with contact sales pricing.
- Customized orphan drug lists
- Seamless split billing integration
- Automated quarterly updates
Selero
Contact Sales
Selero offers an advanced platform for managing and optimizing 340B drug programs with analytics, audit, and claim reporting tools. Available with contact sales pricing.
- Specialty Rx Referral Capture
- Precision-Powered Rx Auditing
- Fully Managed Claim Reporting
Proximity
Contact Sales
Proximity is a comprehensive platform designed to automate and optimize revenue operations for 340B drug programs, ensuring compliance, maximizing savings, and simplifying complex workflows. Notable: Trusted by numerous healthcare organizations and trusted logos. Available with contact sales pricing.
- Automated claims reprocessing
- Real-time data monitoring
- Configurable workflows
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Frequently Asked Questions
What is the best 340b program management tool in 2026?+
Based on our analysis of 5 tools, Aventi Health stands out for its completeness and feature set. Aventi Health offers a comprehensive 340B management platform and third-party administration services focused on specialty and infusion pharmacies, enabling compliant, efficient, and transparent drug discount program management. Over 300 covered entities and 1,000 pharmacies served. However, the best choice depends on your specific needs, team size, and budget.
What features should I look for in 340b program management software?+
The most common features across 340b program management tools include Modern technology tools, Robust reporting and analytics, Seamless onboarding and compliance, Split billing and contract pharmacy software. Prioritize the features that align with your workflow and team size rather than choosing the tool with the longest feature list.
How did SaaS Choice evaluate these 340b program management tools?+
We assessed each tool across pricing transparency, feature completeness, target audience fit, and available social proof. Our completeness score reflects how much reliable information is available for each product, helping you compare tools on an even footing.
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